What is the name of the rule that states A pairs with T and C pairs with G?

What is the name of the rule that states A pairs with T and C pairs with G?

• A. Central dogma
• B. Chargaff's rule
• C. Watson-Crick pairing
• D. Base-pairing rule

Answer: (B)

Chargaff's rule states that in DNA the amount of adenine equals thymine and the amount of cytosine equals guanine. This balance points to complementary pairing between strands, which is why A pairs with T and C pairs with G in the double helix. The rule describes the proportional relationships that underlie the pairing, even though the exact hydrogen-bonding geometry is described by Watson–Crick base pairing. Other terms refer to different ideas (a general base-pairing concept, the specific pairing mechanism, or the flow of genetic information), so Chargaff's rule is the appropriate name for this pairing relationship.

Chargaff's rule states that in DNA the amount of adenine equals thymine and the amount of cytosine equals guanine. This balance points to complementary pairing between strands, which is why A pairs with T and C pairs with G in the double helix. The rule describes the proportional relationships that underlie the pairing, even though the exact hydrogen-bonding geometry is described by Watson–Crick base pairing. Other terms refer to different ideas (a general base-pairing concept, the specific pairing mechanism, or the flow of genetic information), so Chargaff's rule is the appropriate name for this pairing relationship.